Endocrine Abstracts

Resistance to thyroid hormone (RTH) is a rare, autosomal dominant disorder characterised by a reduced sensitivity of peripheral tissues to thyroid hormone. Thyroid function testing shows elevation of free T4 and T3 with non suppressed TSH levels.Vascular function in these patients has not been fully evaluated. We have studied central arterial stiffness in a cohort of RTH patients, comparing them with age and sex matched controls.Me...

Background: Inherited metabolic disorders (IMDs) are a group of heterogenous genetic disorders resulting in substrate accumulation, energy deficiency or complex molecular defects due to the failure of specific molecules to act as enzymes, cofactors, transporters, or receptors in specific metabolic pathways. The pathophysiological changes seen in IMDs sometimes impact on the endocrine system. We here describe our experience at one UK centre where patients are seen jointly by an...

The hippocampus is majorly involved in memory formation. The insulin pathway regulates the level of GSK-3β, which is involved in the formation of amyloid beta and Tau. Allium sativumhas been shown to reduce amyloidogenesis and increase brain insulin sensitivity. 32 male Wistar rats were used in this experiment. They were grouped into 4, each with 8 rats. Group A (Sham), B (3 mg/kg of streptozotocin), group C (3 mg/kg of streptozotocin +300 mg/kg of Allium sat...

Background: MBDP describes inadequate mineralisation of bones in the preterm infant. Traditionally, neonatologists have used a raised ALP and low phosphate to diagnose MBDP, with phosphate supplements as first-line treatment. An alternative management approach, published by Chinoy et al (2019), recommended PTH and vitamin D in the routine work-up. Objectives: We undertook a review of data across two neonatal intensive care units:<p class="ab...

Introduction: The response to SARS-CoV-2 lead to interventions to mitigate the pandemic. We retrospectively analysed the effect of changes on key NET services. These included: change in clinic media, absolute change in numbers for endoscopy and bronchoscopy, nuclear imaging, SSA administration and PRRT numbers compared with 2019.Method: The NET database was analysed. Endoscopy rates on a monthly basis were reviewed. Two bespoke postal patient surveys wer...

Introduction: Pulmonary neuroendocrine tumours (pulNETs) histologically encompass: small cell, large cell, typical (TC) and atypical carcinoid (AC). Diffuse idiopathic pulmonary neuroendocrine hyperplasia (DIPNECH) is a very rare condition but potentially progress to pulNET and is associated with MEN. Advances in treatment have modified management, and there have been recommendations to use Ki67 for grading. However there is a paucity of randomized studies.<p class="abstex...

Background: Timely diagnosis and management of neonatal hypoglycaemia is important due to associated short and long-term sequelae including neurodevelopmental delay. Hyperinsulinism should be distinguished from other causes of hypoglycaemia as management and acceptable glycaemic parameters may be different.Aims: To characterize admissions with hypoglycaemia and assess the use of hypoglycaemia screen to detect hyperinsulinism.Method...

Purpose: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia.Methods: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014. Record-linkage technology (biochemistry, prescribing, hospital admissions, cancer registration, mat...

Background: It is well established that patients with acromegaly have compromised quality of life both during active disease, as well as whilst on remission. (1). In the recent years, there has been increasing emphasis on the importance of considering health-related quality of life (QoL) outcomes in the care of patients with acromegaly. The University Hospitals Birmingham NHS Foundation Trust introduced and implemented the use of a holistic needs assessm...

Purpose: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia.Methods: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014. Record-linkage technology (biochemistry, prescribing, hospital admissions, cancer registration, mat...